Dave, Hsu, Owzar, Katsanis, and Gregory are highly experienced in cancer genomics and have broad collaborations within the program and with other programs that enable the DCI community to use these cutting edge tools. Uses family-based studies and animal models to identify susceptibility loci, particularly for aggressive forms of common cancers. By comparing the sequence of DNA in cancer cells with that in normal cells, such as blood or saliva, scientists can identify genetic changes in cancer cells that may be driving the growth of an individual’s cancer. The program serves to coordinate DCI research activities related to: 2. The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that contribute to cancer susceptibility and progression. The CGG program supports genomic resources for the DCI:  Genomics encompasses a set of enabling high throughput methods that enable the work of researchers throughout the DCI. CGG is further organized into three focus groups: (a) The Focus Group on Genomics, Epigenetics and Model systems. Where applicable, we conduct pathway analysis of targeted genes. Asks questions and develops tools to better understand the evolutionary relationship between genomes. ". 3 (March 19, 2015): e1004656-. The Department of Cancer Genetics and Genomics, through the investigation of the various mechanisms that cells adopt to become cancer cells, is dedicated to improving our understanding of mechanisms and pathways through which cells overcome their normal constraints on proliferation and differentiation and transform into tumor cells. Several members, including Drs. The CGG is at the forefront of applying 'omics' technologies that assess alterations in cancer genomes, epigenomes and transcriptomes, or techniques that are capable of editing the genome or epigenome of a model system. A-K: Profiles of Faculty Working on Cancer Genetics and Genomics They search for causal sequence variants in DNA from inherited cells of at-risk individuals, in human tumor genomes and in the genomes of model organisms such as the dog, which is genetically susceptible to many of the same forms of cancer as humans. Nature Methods 12, no. From the hunt for cancer-related genes to advances in precision medicine, we are expanding the understanding of the genetics and genomics of cancer and using that knowledge to create new treatment options. ", "The Role of EBV in the Pathogenesis of Diffuse Large B Cell Lymphoma. The CGL is mandated to provide molecular genetic diagnostics and paraffin FISH testing for all cancer patients in British Columbia.

Bogerd, HP, Kornepati, AV, Marshall, JB, Kennedy, EM, and, Thakore, PI, D'Ippolito, AM, Song, L, Safi, A, Shivakumar, NK, Kabadi, AM, Reddy, TE, Crawford, GE, and, Liquid Biopsies Smooth Way For Personalized Medicine, With Robust Molecular Tumor Registry "MrT," The Stars Align, Duke Adult Blood and Marrow Transplant Clinic, Duke Cancer Center Cary Radiation Oncology, Duke Regional Hospital Colorectal Surgery, Cancer Support Calendars (Durham & Wake Counties), DCI Center for Prostate & Urologic Cancers, Office of Cancer Research Career Development (OCRCD), Duke Supportive Care & Survivorship Center, "Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators. These are all well-attended and bring together a diverse group of investigators around the central themes of cancer genetics and genomics. 52 (December 14, 2015): E7249-E7256.

In summary, the scientists of the Cancer Genetics and Comparative Genomics Branch work in a highly collaborative and multi-disciplinary setting to answer questions regarding the causes, growth patterns, and treatment responses associated with cancer. Understanding the altered epigenetics and gene expression (transcriptional and post - transcriptional) that occurs in cancers. Proceedings of the National Academy of Sciences of the United States of America 112, no. These tools are applied to  studies of cancer as well as other diseases. We also work with both population scientists and clinicians to define gene profiles that offer predictability in terms of cancer susceptibility, metastasis, and outcomes. 22 (November 2015): 11523-11533. Identifying Genetic Changes in Cancer.

Thus, genomics expertise is disseminated to all DCI members through the focus groups and program-wide activities. ", "Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. Applies genomic technologies for molecular diagnosis of rare diseases with profound cancer susceptibility, such as Fanconi anemia. Sandeep Dave, MD, MS is a physician-scientist and clinical oncologist. "Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity."

", "Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. (c) The Focus Viral Oncology and Microbiomes. These research efforts are conducted both independently and through collaborative agreements with universities, academic medical centers, and clinics. (b) The Focus Group on DNA Recombineering and Repair. PLoS Pathogens 11, no. He is the PI of several peer-reviewed grants including two R01 grants and an R21 grant from the NCI as well those from other agencies including the Leukemia Lymphoma Society and the Department of Defense. © 2020 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Expanding the Impact of Precision Medicine to Fuel Discoveries, A New Mouse? For example, the discovery of cancer-causing genetic and epigenetic changes in tumors has enabled the development of therapies … The focus group activities provide additional opportunities for training, mentorship and interaction around more focused themes. This is just one more way of ensuring your safety and that of our staff. Supports the development of genomic techniques specific for development of model organisms and the use of mouse and other small animal models for cancer-related genetic and functional studies. The CGG program features enhanced interactions among program investigators and with investigators of other DCI programs. Current Topics in Microbiology and Immunology 390, no. He completed medical school and graduate school at Northwestern University, and a clinical and post-doctoral fellowship at the National Institutes of Health.

The branch is committed to training and providing opportunities to scientists from traditionally under represented groups. A particular strength of the CGG program is the genomics expertise that resides in the program. Lab tests called DNA sequencingtests can “read” DNA. Finally, we utilize state of the art approaches in all phases of our work and we seek to develop and contribute advances in genomic technology to all fields of human health and biology. "The Role of EBV in the Pathogenesis of Diffuse Large B Cell Lymphoma." 12 (December 2015): 1143-1149.

Cancer Genetics and Genomics (CGG) Specific Aims. Conducts research on multiple types of cancer, including (but not limited to) cancers of the prostate, endometrium, lung, bladder, and breast; melanoma, and Fanconi anemia. PMID: 25790223.

Genomics, Epigenetics and Model systems (Leader, Dr. Beth Sullivan), 2. Application of genomics technologies to assay alterations in cancer genomes, epigenomes and transcriptomes. Provides public education seminars and Continuing Medical Education lectures to support groups, clinicians, university departments, and other groups interested in the research being conducted by Branch Investigators. The Cancer Genetics and Genomics Research Program (CGG) serves to coordinate the Duke Cancer Institute (DCI) research activities related to the study and understanding of cancer genomics, epigenetics, gene expression, model systems and host interactions. They also study the relationship between genetic variation and cancer progression and pursue the discovery of both inherited and somatic variants that lead, specifically, to fast-growing and aggressive tumors. We are closely monitoring this rapidly evolving situation and are implementing all necessary precautions to prevent the spread of infection.

Advanced genomic testing may help find gene mutations that may be driving a cancer’s behavior.

Genomics refers to the molecular composition of a tumor.

Importantly CGG encourages strong interactions between its members and those of clinical programs as a route to translate the basic science findings obtained by the CGG program.

PMID: 26355084, Price, AM, and Luftig, MA. Develops and maintains banks of normal and tumor tissue (consisting of both germline and tumor DNA) for a variety of types of cancer. Love et al, Nature Genetics 2012) and for understanding the molecular underpinnings of response to targeted therapies (e.g. Journal of Virology 89, no. Branch investigators develop and implement new technologies and bioinformatics tools for genome analysis that are integral to this discovery pipeline.

These data provide a rich source of information for aggregation to interpret cancer related mechanisms. The Duke Cancer Institute (DCI) wants to assure our patients that the safety of our patients, their loved ones, our team members and the community at large remains our highest priority.

Walsh et al, Clin Canc Research 2013). "To be or not IIb: a multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis." This investment has in turn enabled a number of inter-program and inter-institutional collaborations within the DCI and beyond. Conducts individual and consortium-based collaborations with epidemiologists using genome-wide association studies to provide support for quality-of-life studies. Viral Oncology and Microbiomes (Leaders, Drs. Could a Blood Test Detect Early-Stage Cancers. The advent of high throughput sequencing and genome editing provides powerful technologies that allow the high resolution definition of molecular aberrations of tumors and the tools to explore these mutations in an in vitro and in vivo setting. Pt 1 (January 2015): 315-337. In addition we perform whole exome and genome sequencing of both germline DNA and tumors. Read more. His work has applied high throughput sequencing to unravel the genetic causes of lymphoma (e.g.

Both types of tests may help you and your doctor make informed decisions about the types of treatment that should be … Cancer is a disease of disordered genetic and epigenetic regulation. Through targeted investment in high throughput genomics, the DCI has enabled collaborations around high throughput sequencing, and transgenic mouse and RNAi facilities. Cancer Genetics & Genomics Whether they occur by chance or due to environmental factors or inherited predisposition, cancers are fundamentally genetic diseases, triggered by mutations that lead to abnormal cell growth. In close collaboration with Michael Kastan, PhD, executive director of Duke Cancer Institute, the program leaders have re-invigorated this program by merging two pre-existing programs, re-evaluating the membership, identifying the leadership for focus groups, and recruiting new faculty to Duke and the DCI. Whether they occur by chance or due to environmental factors or inherited predisposition, cancers are fundamentally genetic diseases, triggered by mutations that lead to abnormal cell growth. 3. Jinks-Robertson moved to Duke in 2006 and currently is vice chair of her department and director of the T32-funded Cell and Molecular Biology graduate training program.